An allergy is a pathological reaction of the immune system which is manifested as to certain substances – allergens. A human faces thousand substances every day that may cause an unusual reaction of the immune system. These are dust, pollen, animal hair, medicines, food, inedible things, fabric, industrial releases, etc. Any ingredient may be an allergen and cause a rejection in the body. Moreover, a human can have a pet or take certain food but this person will have an allergy the other day.
It is impossible to prevent a development of the allergic process because you do not know what exactly causes a reaction of the immune system. But the advanced medicine has learned to cope with the allergy symptoms.
The main cause of the development of an allergic reaction is a production of the allergy mediators by the protective properties of the body, and histamine is the main. The body has histamine in a non-active type, and more histamine is produced during the aggravation of the pathological process, it is kind of a reaction of the immune system.
The free histamine has a high activity: it causes spasm of the smooth muscles (including muscles of the bronchi). As a result of the dilation of the capillaries and a decrease of the blood pressure, the blood congestion happens, the capillary permeability is increased. It leads to the edema of the tissues and the blood thickening.
The histamine receptors are placed all over the tissues, and therefore the allergic reaction may appear in any place and be manifested in a various way. These are reactions in the central nervous system, the respiratory system, the skin, etc.
The standard therapy of an allergy includes the use of the antihistamine products that reduce a production of histamine. But if there is a failure in the work of the immune system and the allergic shock or acute urticaria has appeared, the allergy can be stopped only by means of Prednisolone.
Prednisolone is not only an effective blocker of the histamine receptors but also a strong immunosuppressive agent. It slows down the protective processes of the body and reduces the reaction to the action of the allergens.
Prednisolone is an analog of the adrenal hormones produced in a low amount by the body. They prevent the shock states, regulate the metabolic processes and resist the acute inflammatory processes. But when the pathological allergic process causes an acute reaction, the body is not able to produce enough amount of the hormones. Prednisolone helps to makeup the lack of the adrenal hormones and regulate the internal processes.
The mechanism of the action of Prednisolone is conditioned by the immunosuppressive properties during the allergic reaction. It inhibits most biochemical processes which occur during the acute allergic reaction.
The drug also:
Prednisolone acts systemically, and due to this it arrests both local, and general allergic process regardless of its severity. Due to the vast action on the body, Prednisolone is able to reduce the allergy shock, Angioedema, and other dangerous symptoms of the allergy.
Prednisolone is produced in various medical forms, and it helps to use it for various types of the allergy. As it is a hormone drug that may cause many side effects, the daily use of the pill is unreasonable. It is better to use ointment for the external application during some types of the allergy.
The ointment having Prednisolone is used for:
The ointment is applied with a thin layer on the skin with rash, edema, redness, or itching. Prednisolone ointment is applied 1 to 3 times per day depending on the intensity of the allergy manifestations.
As it is absorbed into the skin after the application of the drug, it is also absorbed into the systemic blood flow, its concentration is low in order to cause serious side effect. Therefore, in case of the external types of the allergy, it is recommended to mainly use Prednisolone ointments. If severe types of the allergy, patients are prescribed ointment and pills of Prednisolone.
The Prednisolone pills are prescribed to prevent the allergy. The use of the pills helps to control the immune system for a long period and inhibit the symptoms of the allergic reaction. The pills are taken for a long period, 2-4 times per day. A daily dose of Prednisolone is 15-20 mg to treat the allergy. The dose is usually divided into several equal parts and taken with the interval of 5-6 hours. This way, the concentration of Prednisolone is kept 24 hours on the same level in the blood.
The Prednisolone injections are recommended for Angioedema, allergy shock, or acute urticaria with the affection of more than 70% of the human skin. The therapeutic effect occurs within 5-10 minutes during the intramuscular injection of Prednisolone, and so the dangerous manifestations are arrested.
Acute bronchospasm, brain edema, acute intoxication, any types of shock are the indications for the use of Prednisolone in the form of the injections. The injections are given as fast as possible after the first symptoms of the allergic reaction.
The Prednisolone injections are used only in severe states requiring an instant treatment. In the rest cases, the pills and ointments are preferable.
Prednisolone is quickly absorbed in the gastro-intestinal tract and gains the maximal concentration in the blood in an hour after the use of the pill, but a stable anti-allergic action may be achieved in several days of the drug use. The production of histamine can be blocked in several minutes, and it is rather difficult to achieve the intensive change of the immune reaction of the body to the action of allergens.
So, a patient may have the attacks of the allergy in the first days of the use of Prednisolone: urticaria, itching, edemas, but these symptoms will be light. In a week of the daily use of Prednisolone pills, the immune reaction will be reduced, and the allergy manifestations will stop bothering a patient.
Recommendations for the use of Prednisolone pills:
The use of the Prednisolone pills is not terminated right away. When the stable anti-allergic action is achieved, the daily dose is reduced by 2,5-5 mg every 5 days. This way, you will avoid side effects.
You can buy Prednisolone at any time in the internet pharmacy. Online pharmacies work 24/7, and Prednisolone is for sale even on holidays.
Knowing an urgent need of patients, most pharmacies send the package with the drug instantly after paying for the order. Prednisolone is for sale in the dose of 5 mg, 10 mg, 20 mg, and 40 mg in the online pharmacy.
Depending on a dose and number of pills in a pack, a cost will vary. The average cost of Prednisolone is the following in the internet pharmacy (buying 120 pills):
|Dosage||Cost per pill|
|Prednisolone 5 mg||$0.44|
|Prednisolone 10 mg||$0.67|
|Prednisolone 20 mg||$0.69|
|Prednisolone 40 mg||$0.91|
Moreover, the more the pills of Prednisolone you order, the more the discount will be. Buying 180 pills, a cost per pill of Prednisolone is reduced by 11%.
Prednisolone is a strong hormone drug, and therefore it has a big list of the contraindications. It is necessary to be ready that a doctor will prohibit the use of this drug due to the health reasons.
You should not neglect the precautions, and do not take the pills during:
There are many contraindications but you should know that there are conditions which can cancel all restrictions, for instance, Angioedema, or allergy shock. A human may die of these conditions if Prednisolone is not used in time.
As to the important peculiarities of the treatment, patients have to stick to the following rules: